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Herbert Edgar Wyndham was born in Manchester, England. While a student at Oxford in the 1930s, he took an interest in the work of heretical biologist Nathaniel Essex, and began experimenting with genetic manipulation, building a machine (that he called the genetic accelerator) with which he attempted to "evolve" the rats in his mother's London basement. While attending a genetics conference in Geneva, Wyndham was approached by a mysterious man (in truth, the outcast Inhuman geneticist Phaeder) who handed to him papers containing blueprints for cracking the genetic code. With this information to bolster his experiments, Wyndham successfully developed a serum he dubbed "Isotope A."
Although expelled from the university for his single-mindedness, he finally succeeded in evolving his pet Dalmatian, Dempsey, into a humanoid life form with the intelligence of a chimpanzee. Dempsey, unfortunately, was shot by poachers, and Wyndham realized that such creatures as he would create would have no place in the human world. In partnership with scientist Jonathan Drew (father of Jessica Drew), Wyndham moved his experiments to the seclusion of Wundagore Mountain in the small Balkan nation of Transia. Discovery of uranium on the land (inherited by Drew's wife) provided vast funding, and they bought more land from local baron Gregor Russoff.
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